Osmotic Swelling Induces p75 Neurotrophin Receptor (p75NTR) Expression via Nitric Oxide
نویسندگان
چکیده
منابع مشابه
CD 271 (P75 neurotrophin receptor).
P75NTR (or CD271) is a member of the Tumor Necrosis Factor receptor (TNFR) super family of transmembrane proteins that share significant homology in their extracellular domains. Subsets of TNF receptors, including CD271, have a cytoplasmic death domain, although CD271 has unique intracellular structure and downstream signaling partners. CD271 is also differentiated from other members of the TNF...
متن کاملBrief Communication A Pro-Apoptotic Fragment of the p75 Neurotrophin Receptor Is Expressed in p75NTR Null Mice
The p75 neurotrophin receptor (p75NTR) regulates neuronal survival, apoptosis, and growth. Recent studies have reported that disruption of Exon IV produces a null mouse lacking all p75NTR gene products (p75NTR ExonIV / ), whereas mice lacking p75NTR Exon III (p75NTR ExonIII / ) maintain expression of an alternatively spliced form of p75NTR (s-p75NTR). Here, we report that p75NTR ExonIV / mice e...
متن کاملNeurotrophin Receptor p75NTR Regulates Immune Function of Plasmacytoid Dendritic Cells
Plasmacytoid dendritic cells (pDCs) regulate innate and adaptive immunity. Neurotrophins and their receptors control the function of neuronal tissue. In addition, they have been demonstrated to be part of the immune response but little is known about the effector immune cells involved. We report, for the first time, the expression and immune-regulatory function of the low affinity neurotrophin ...
متن کاملBlockade of p75 Neurotrophin Receptor Reverses Irritability and Anxiety-Related Behaviors in a Rat Model of Status Epilepticus
Background: Many recent epidemiological studies have shown that epileptic patients are more likely suffer from depression, anxiety, and irritability. However, the cellular mechanisms of epilepsy-induced psychotic behaviors are not fully elucidated. Neurotrophin receptors have been suggested to be involved in epilepsy and also in psychiatric disorders. Up-regulation of p75NTR expression and acti...
متن کامل-Amyloid to the p75 Neurotrophin Receptor Induces Apoptosis A Possible Mechanism for Alzheimer’s Disease
Alzheimer’s disease is a neurodegenerative disorder characterized by the extracellular deposition in the brain of aggregated b -amyloid peptide, presumed to play a pathogenic role, and by preferential loss of neurons that express the 75-kD neurotrophin receptor (p75 NTR ). Using rat cortical neurons and NIH-3T3 cell line engineered to stably express p75 NTR , we find that the b -amyloid peptide...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2003
ISSN: 0021-9258
DOI: 10.1074/jbc.m302376200